博士生导师,教授,澳门新葡萄新京app官网“杰出人才特区支持计划”第四层次特聘教授。在中山大学获学士和硕士学位,在澳大利亚悉尼大学医学院获博士学位。邮箱:li2002jia@hotmail.com。李佳博士致力于血管异常疾病,包括肿瘤,心脑血管,糖尿病血管并发症等疾病的研究以及血管纳米靶向(脑靶向,肿瘤靶向及炎症靶向)药物递送系统的建立。李佳教授与悉尼大学研究人员合作开发出世界第一款处于临床试验阶段的核酸药物用于修复破损血管,恢复正常血管功能,在皮肤癌/肝癌,脑海绵体畸形,糖尿病眼底血管病变中具有良好的治疗效果。其先后获得澳大利亚国立卫生及健康研究委员会Gustav Nossal Award (每年仅一名,授予全澳排名第一的生物医学及临床医学青年学者,获澳大利亚卫生部长颁奖),澳大利亚国立卫生及健康研究委员Research for Excellence Award (年度卓越研究奖),澳大利亚血管医学会最佳研究奖和悉尼大学心血管药物研究突出青年奖。并主持澳大利亚健康与医学研究委员会项目和中国国家自然科学基金面上项目。其研究论文发表于Blood, PLoS Biology,Cancer Research,Science Advances, Diabetologia,Advanced Materials, Small及Cancer letters等期刊。
五篇代表作:
[1] Jia Li, Daniel M-Y Sze, Ross D Brown, Mark J Cowley, Warren Kaplan, Sui-Lin Mo, Shihong Yang, Esther Aklilu, Karieshma Kabani, Yen S Loh, Tetsuo Yamagishi, Yuling Chen, P Joy Ho, Douglas E Joshua . Clonal expansions of cytotoxic T cells exist in the blood of patients with Waldenström macroglobulinemia but exhibit anergic properties and are eliminated by nucleoside analogue therapy. Blood. 2010;115 (17): 3580–3588.
[2] Jia Li, Yang Zhao, Jaesung Choi, Ka Ka Ting, Paul Coleman, Jinbiao Chen, Victoria C Cogger, Li Wan, Zhongsong Shi, Thorleif Moller, Xiangjian Zheng, Mathew A Vadas, Jennifer R Gamble. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy. PLoS Biology. 2020;18(6): e3000734.
[3] Jennifer A Young#, Ka Ka Ting#, Jia Li#, Thorleif Moller, Louise Dunn, Ying Lu, Angelina J Lay, Joshua Moses, Leonel Prado-Lourenço, Levon M Khachigian, Martin Ng, Philip A Gregory, Gregory J Goodall, Anna Tsykin, Ilana Lichtenstein, Christopher N Hahn, Nham Tran, Nicholas Shackel, James G Kench, Geoffrey McCaughan, Mathew A Vadas, Jennifer R Gamble. Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27. Blood. 2013;122 (16): 2911–2919. (# first author)
[4] Jia Li, Yang Zhao, Ying Lu, William Ritchie, Georges Grau, Mathew A Vadas, Jennifer R Gamble. The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b. Mol Ther Nucleic Acids. 2016;5(8):e354.
[5] Yang Zhao#, Jia Li#, Ka Ka Ting, Jinbiao Chen, Paul Coleman, Ken Liu, Li Wan, Thorleif Moller, Mathew A Vadas, Jennifer R Gamble. The VE-Cadherin/β-catenin signalling axis regulates immune cell infiltration into tumours. Cancer Lett . 2021;496:1-15. (# first author)